Enantioselective Total Synthesis of Fluvirucinin B1.

نویسندگان

  • Guillaume Guignard
  • Núria Llor
  • Elies Molins
  • Joan Bosch
  • Mercedes Amat
چکیده

A convergent synthesis of fluvirucinin B1 from acid ent-6a and nitrile ent-9, involving an organocopper coupling, a stereoselective allylation, a ring-closing metathesis reaction, and a stereoselective hydrogenation as the key steps, is reported. The starting building blocks have been prepared in a straightforward manner from a common phenylglycinol-derived lactam 1. An unprecedented regioselective oxidation of phenylglycinol-derived secondary amines 5 to carboxylic acids 6 has been developed.

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عنوان ژورنال:
  • Organic letters

دوره 18 8  شماره 

صفحات  -

تاریخ انتشار 2016